
destination guide
Published by Mercer Stays Team on Jun 2, 2026
There's something undeniably thrilling about a casino weekend—the anticipation of the games, the upscale dining, the late-night energy that keeps you coming back for more. St. Charles, Missouri, delivers all of this and more with two world-class gaming destinations: Ameristar Casino and Hollywood Casino. But here's what most visitors don't realize: staying in a cramped casino hotel room isn't your only option. At Mercer Stays, we've watched countless guests discover that a spacious vacation home transforms a good casino trip into an unforgettable getaway.
Whether you're planning a couples' escape, a birthday celebration, or a friends' reunion centered around poker tables and slot machines, this guide covers everything you need to know about maximizing your Ameristar casino St. Charles weekend.
St. Charles sits at a unique crossroads of entertainment and charm. Just 30 minutes from downtown St. Louis, this historic river city offers the excitement of major gaming venues without the overwhelming bustle of a massive metropolitan area.
Ameristar Casino Resort features over 130,000 square feet of gaming space, including thousands of slot machines, table games ranging from blackjack to craps, and a dedicated poker room for serious players. The property also boasts multiple restaurants, a spa, and regular entertainment events that keep the energy flowing well past midnight.
Hollywood Casino St. Louis, located just across the Missouri River in Maryland Heights, provides another excellent option with its own distinctive atmosphere, gaming floor, and dining experiences. Many savvy visitors hit both casinos during a single weekend, maximizing their entertainment options.
The beauty of choosing St. Charles for your casino vacation rental experience lies in the flexibility. You're not locked into casino hotel prices that spike on weekends, and you gain access to full kitchens, multiple bedrooms, and amenities that hotels simply can't match. Browse our entire home rentals near Ameristar Casino to see what a real difference extra space makes.
Arrive in St. Charles early enough to settle into your vacation rental before the evening action begins. This is where staying in a private home pays dividends—you can freshen up properly, perhaps enjoy a cocktail on your own patio, and head to the casino feeling relaxed rather than rushed.
For your first night, consider starting at Ameristar's gaming floor around 7 PM. The Friday night crowd brings energy without the Saturday peak intensity, making it ideal for warming up at the tables. Take time to explore the different sections, find your lucky machines, and scope out the table game minimums.
Pro tip: Set your gambling budget before you walk through those doors. Experienced casino visitors know that managing bankroll is the difference between a fun weekend and a disappointing one.

For groups planning a St. Charles casino trip together, the St. Charles Manor | 4BR Reunion Home+HotTub+GameRm offers the perfect home base. With four bedrooms, a hot tub for post-casino relaxation, and a game room for continuing the fun at home, it's designed for memorable group getaways.
Saturday is prime time for serious casino action, but smart players know to pace themselves. Start your day with a hearty breakfast at your rental—those full kitchens mean you can fuel up properly without paying casino restaurant prices for eggs and coffee.
Hit the casino floor mid-morning when crowds are lighter and table minimums may be lower. By early afternoon, take a break to explore the St. Charles Historic District. The charming Main Street offers antique shops, local boutiques, and riverfront views that provide a refreshing contrast to the casino atmosphere. This break keeps you sharp for the evening session.
If you're also interested in exploring the area during your Hollywood Casino St. Louis stay, consider checking out our guide to Main Street Saint Charles and spring street music festivals for additional entertainment options.
Return to the casino floor for Saturday evening's peak excitement. This is when the energy reaches its height—live entertainment, packed poker rooms, and that unmistakable buzz of possibility. Many visitors prefer trying Hollywood Casino on Saturday night for variety, especially if they spent Friday at Ameristar.
Wind down your weekend with a leisurely morning. One of the greatest advantages of casino vacation rentals in St. Charles is having space to decompress. Soak in the hot tub, make brunch, and count your winnings (or commiserate over near-misses with friends).
Before heading home, many guests enjoy a final stroll through downtown St. Charles or a casual lunch at a local restaurant. This slower Sunday pace ensures you return home feeling refreshed rather than exhausted—a crucial difference from the typical "casino hotel checkout rush."
Let's be honest about why savvy casino visitors increasingly choose vacation rentals over hotel rooms:
Space: Casino hotel rooms are notoriously compact. After hours on a crowded gaming floor, returning to a cramped room with nowhere to spread out feels suffocating. A full vacation home offers living rooms, multiple bathrooms, outdoor spaces, and room to breathe.
Value: Casino hotel rates spike dramatically on weekends—often $250-400+ per night for a basic room. Split a spacious vacation rental among friends, and your per-person cost drops significantly while your comfort level increases.
Privacy: No housekeeping knocks at inconvenient hours, no thin walls transmitting neighbor noise. Just your own private retreat.
Amenities: Hot tubs, game rooms, full kitchens, and multiple TVs aren't extras you pay for—they're standard.

For couples seeking a romantic casino getaway, the St. Charles Manor | 2BR Hot Tub Chalet | 1.2 Acres delivers intimate luxury. Imagine returning from the excitement of the casino floor to your own private chalet, sinking into the hot tub under the stars, and having 1.2 acres of peaceful surroundings to yourselves.
Mercer Stays offers properties specifically positioned for easy casino access. Our affordable Airbnb options near Ameristar Casino prove you don't have to sacrifice quality for budget-consciousness.
Join the Players Clubs: Both Ameristar and Hollywood Casino offer loyalty programs. Sign up before you play your first hand—you'll earn points toward free play, dining credits, and hotel discounts (though you won't need those hotel discounts when you're staying in a comfortable vacation rental).
Know the Table Minimums: Minimums fluctuate based on day and time. Weekday afternoons often offer $10-15 minimums, while Saturday nights might jump to $25-50. Plan your serious table play accordingly.
Eat Strategically: Casino restaurants are convenient but pricey. Having a full kitchen at your vacation rental means enjoying a proper breakfast before you head out and late-night snacks when you return, reserving your dining budget for one memorable casino meal.
Pace Your Sessions: The most successful casino visitors take regular breaks. Step outside, grab coffee, return to your rental for a power nap. Fresh minds make better decisions—both at the tables and at the slot machines.
Explore Beyond the Casino: St. Charles offers excellent dining, boutique shopping, and outdoor activities along the Missouri River. A weekend that balances gaming with local exploration is more memorable than 48 hours of non-stop gambling.
While the casinos anchor your weekend, St. Charles delivers entertainment beyond gaming. The historic district's cobblestone streets and 19th-century architecture create a picturesque backdrop for afternoon wandering. Local restaurants serve everything from upscale American cuisine to casual riverfront dining.
For those extending their stay, Mercer Stays properties also provide easy access to attractions like Mastermind Room Escape (perfect for group bonding), The Family Arena for concerts and events, and STL Axe Throwing for a different kind of competitive thrill.
If you're planning a larger celebration, consider our Father's Day St. Charles weekend guide for combining casino action with family-friendly activities.

Groups seeking the ultimate entertainment package will appreciate the St. Charles Manor | 4BR Getaway Home+HotTub+GameRm. The combination of hot tub relaxation and a game room means the fun continues long after you've left the casino floor.
Your Ameristar casino St. Charles weekend deserves more than a standard hotel room. It deserves space to celebrate wins, comfort to shake off losses, and amenities that make the trip special regardless of how the cards fall.
Mercer Stays specializes in creating the perfect home base for casino visitors—properties with easy access to both Ameristar and Hollywood Casino, combined with the comfort and privacy that make a weekend truly memorable.
Ready to experience the difference? Browse our complete collection of Airbnb rentals in Saint Charles and find the perfect property for your next casino adventure. Your lucky getaway starts with the right place to stay.